![Polo-like kinases: structural variations lead to multiple functions | Nature Reviews Molecular Cell Biology Polo-like kinases: structural variations lead to multiple functions | Nature Reviews Molecular Cell Biology](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fnrm3819/MediaObjects/41580_2014_Article_BFnrm3819_Fig1_HTML.jpg)
Polo-like kinases: structural variations lead to multiple functions | Nature Reviews Molecular Cell Biology
![Cancers | Free Full-Text | The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor Metastasis | HTML Cancers | Free Full-Text | The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor Metastasis | HTML](https://www.mdpi.com/cancers/cancers-09-00131/article_deploy/html/images/cancers-09-00131-g001-550.jpg)
Cancers | Free Full-Text | The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor Metastasis | HTML
![Frontiers | Polo-Like Kinase 4's Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy Frontiers | Polo-Like Kinase 4's Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy](https://www.frontiersin.org/files/MyHome%20Article%20Library/587554/587554_Thumb_400.jpg)
Frontiers | Polo-Like Kinase 4's Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy
Polo-Like Kinase 1 Directs Assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF Complex to Initiate Cleavage Furrow Formation | PLOS Biology
![Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis | Nature Communications Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis | Nature Communications](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41467-019-12619-2/MediaObjects/41467_2019_12619_Fig1_HTML.png)
Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis | Nature Communications
![A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition | JACC: Basic to Translational Science A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition | JACC: Basic to Translational Science](https://www.jacc.org/cms/asset/b4534caf-efa2-4908-9ae2-27102a4b0e9e/fx1.jpg)
A Role for Polo-Like Kinase 4 in Vascular Fibroblast Cell-Type Transition | JACC: Basic to Translational Science
![Polo-like Kinase 1 Inhibitors in Human Cancer Therapy: Development and Therapeutic Potential | Journal of Medicinal Chemistry Polo-like Kinase 1 Inhibitors in Human Cancer Therapy: Development and Therapeutic Potential | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/acs.jmedchem.2c00614/asset/images/large/jm2c00614_0018.jpeg)
Polo-like Kinase 1 Inhibitors in Human Cancer Therapy: Development and Therapeutic Potential | Journal of Medicinal Chemistry
![Anticancer effects of radiation therapy combined with Polo-Like Kinase 4 (PLK4) inhibitor CFI-400945 in triple negative breast cancer - The Breast Anticancer effects of radiation therapy combined with Polo-Like Kinase 4 (PLK4) inhibitor CFI-400945 in triple negative breast cancer - The Breast](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/attachment/828ba654-3e15-4381-a727-22187db39a12/gr1.jpg)
Anticancer effects of radiation therapy combined with Polo-Like Kinase 4 (PLK4) inhibitor CFI-400945 in triple negative breast cancer - The Breast
![Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131) - Journal of Biological Chemistry Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131) - Journal of Biological Chemistry](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/4eeb1152-364d-4a1d-8853-26e184b9575b/gr1.jpg)
Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131) - Journal of Biological Chemistry
![Frontiers | Polo-Like Kinase 4's Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy Frontiers | Polo-Like Kinase 4's Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy](https://www.frontiersin.org/files/Articles/587554/fonc-11-587554-HTML/image_m/fonc-11-587554-g002.jpg)
Frontiers | Polo-Like Kinase 4's Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy
![Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent: Cancer Cell Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent: Cancer Cell](https://www.cell.com/cms/attachment/fa4a0e8e-8605-4492-977c-69cfb2f73188/gr2_lrg.jpg)
Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent: Cancer Cell
![Asterless is a Polo-like kinase 4 substrate that both activates and inhibits kinase activity depending on its phosphorylation state | Molecular Biology of the Cell Asterless is a Polo-like kinase 4 substrate that both activates and inhibits kinase activity depending on its phosphorylation state | Molecular Biology of the Cell](https://www.molbiolcell.org/cms/10.1091/mbc.E18-07-0445/asset/images/medium/mbc-29-2874-g001.gif)
Asterless is a Polo-like kinase 4 substrate that both activates and inhibits kinase activity depending on its phosphorylation state | Molecular Biology of the Cell
![Polo-like kinases: structural variations lead to multiple functions | Nature Reviews Molecular Cell Biology Polo-like kinases: structural variations lead to multiple functions | Nature Reviews Molecular Cell Biology](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fnrm3819/MediaObjects/41580_2014_Article_BFnrm3819_Fig3_HTML.jpg)
Polo-like kinases: structural variations lead to multiple functions | Nature Reviews Molecular Cell Biology
![Cancers | Free Full-Text | The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor Metastasis | HTML Cancers | Free Full-Text | The Emerging Role of Polo-Like Kinase 1 in Epithelial-Mesenchymal Transition and Tumor Metastasis | HTML](https://www.mdpi.com/cancers/cancers-09-00131/article_deploy/html/images/cancers-09-00131-g002.png)